Knee osteoarthritis Knee osteoarthritis Osteoarthritis of the knee Gonarthrosis OA knee Total knee arthroplasty Total knee replacement TKA TKR Cold solution irrigation Cold saline irrigation Intraoperative cryo
Conditions
Interventions
Mixed cold solution,
consisted of 0.9% NaCl solution 1000 mL and 10% Povidone iodine 250 mL both were stored at 2-
8 degree celsius,
irrigation intraoperatively during TKA procedure,Mixed room temperature solution,
consisted of 0.9% NaCl solution 1000 mL and 10% Povidone iodine 250 mL both were stored at 25-
28 degree celsius,
irrigation intraoperatively during TKA procedure
Experimental Procedure/Surgery,No Intervention Procedure/Surgery
Cold solution irrigation,Room temperature soulution irrigation
Sponsors
Research unit
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: Age > 45 years old Knee osteoarthritis patients who underwent unilateral primary TKA
Exclusion criteria
Exclusion criteria: Cold intolerance/Cold allergy History of previous knee surgery deeper than subcutaneous layer Secondary osteoarthritis from inflammatory joint diseases Chronic kidney disease eGFR < 50 mL/min/1.73m2 Allergy to/Contraindicated to drug in protocol (Tranexamic acid, ketorolac, levobupivacaine, morphine, parecoxib, eperisone, paracetamol, codeine, celecoxib, pregabalin) Documented psychiatric or cognitive impairment disorder Documented coagulation disorder Not enough duration of withholding antiplatelet (except low dose aspirin < 162mg/day) /anticoagulant/herb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score every 4 hours for 72 hours postoperatively Numeric rating scale 0-10 | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioids consumption 72 hours postoperatively Total dose of morphine equivalent per kilogram,Blood loss 72 hours postoperatively Hemoglobin difference, Total drain content, Calculated estimated blood loss (Mercuriali formula) | — |
Countries
Thailand
Contacts
Public ContactPacharapol Udomkiat
Department Orthopedic Surgery, Mahidol University Faculty of Medicine Siriraj Hospital
Outcome results
None listed