Effect of 0.9% NaCl on incidence of hyperchloremic metabolic acidosis

Incidence of hyperchloremic metabolic acidosis in the use of balanced salt crystalloid group or 0.9 NaCl with Acetar group for general anesthesia in craniotomy for tumor removal

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200703004

Enrollment

Unknown

Registered

2020-07-03

Start date

2015-11-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurosurgical patients crystalloid hyperchloremic metabolic acidosis

Interventions

balanced salt crystalloid,combining two crystalloid

Active Comparator Drug,Experimental Drug

sterofundin,0.9% NaCl with Acetar (1:1)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: patient aged 18-65 year old ASA 1-3 Craniotomy for tumor removal

Exclusion criteria

Exclusion criteria: Recieve diuretics diabetic insipidus SIADH emergency surgery

Design outcomes

Primary

Measure	Time frame
incidence of hyperchloremic metabolic acidosis 1 hr and 1 day post operative period percentage	—

Secondary

Measure	Time frame
electrolyte profile 1 hr and 1 day post operative period Electrolyte concentration	—

Countries

Thailand

Contacts

Public ContactChuthit Keesakul

Faculty of Medicine, Ramathibodi Hospital

c_keesakul@hotmail.com022011513

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026