Diabetes type I Diabetes,
Conditions
Interventions
Daily 500 mg for 7 days and then gradually increased by 2000 mg based on the weight of the adolescent. When the fasting blood sugar was less than 70 mg/dl,
routine dose of insulin decreased just 1 unit and when it was more than 130 mg/dl,
2 units of insulin dose was increased. Actually the routine treatment was inslunin in which in this group metformin was added. ,Taking routine insulin for the treatment of diabetes type I.
Experimental Drug,Experimental Drug
Metformin+insulin,Insulin
Sponsors
Shahid BeheshtiUniversity of Medical Sciences
Shahid BeheshtiUniversity of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 20 Years
Inclusion criteria
Inclusion criteria: The factors including age 10 to 20 years, diabetes infliction for more than a year, manifestation of diabetic ketoacidosis, the lack of history of diabetes in the family, treatment with multiple daily insulin injections from at least one year ago, receiving of instruction on how to control diabetes at the Children's Endocrine Clinic at least a year ago, the dose of insulin more than one unit per kilogram of body weight, and hemoglobin A1C levels more than 8% over the past six months were considered as inappropriate control criteria for entry into the study.
Exclusion criteria
Exclusion criteria: The excluding criteria were nephropathy (excretion of more than 200 g of albumin per minute), incidence of diabetic ketoacidosis more than twice a year, proliferative retinopathy, current insulin therapy by conventional method, times of incidence per year, severe and recurrent hypoglycemia, along with decreased level of consciousness, having more than two seizures over the past year (liver or kidney dysfunction, concomitant serious illness, and eating disorders).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBA1C 4 points: Before and after intervention every 3 months Blood sampling | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin 4 points: Before and after intervention every 3 months Sampling | — |
Countries
Iran
Contacts
Public ContactZahra Eydian
Shahid Beheshti University of Medical Sciences
Outcome results
None listed