Acute kidney injury or chronic kidney injury participants who underwent acute hemodialysis Locking solution,
Conditions
Interventions
Use as locking solution in Double lumen in setting of acute hemodialysis participants after procedure and every sessions of hemodialysis,
dosage of solution is 1 ml dilute in NSS up to 3 ml and used amount of description in A-
line and V-
line on double lumen catheter,Use as locking solution in Double lumen in setting of acute hemodialysis participants after procedure and every sessions of hemodialysis,
dosage of solution are add on 0.1 ml amount of dosage description in A-
line on double lumen catheter,
not diluted with NSS
Placebo Comparator Drug,Active Comparator Drug
Heparin locking solution,7.5% NaHCO3 locking solution
Sponsors
Vajira hospital research foundation
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.age > 18 yr 2.participants with non cuff venous catheter 3. participants receiving hemodialysis
Exclusion criteria
Exclusion criteria: 1.participants received warfarin, NOAC, or systemic heparin infusion 2.participants with abnormal coagulopathy 3 participants with history of CRBSI at least three months before study 4.participants with history of hypersensitivity to heparin 5. pregnancy 6. participants with low platelet count 30 mmol/dL 9.participants with symptomatic hypocalcemia 10.. participants does not consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy and safety 28 day Catheter day function,Compare rate of complication 28 days Catheter dysfunction; thrombosis, fibrin sleeves, CRBSI | — |
Secondary
| Measure | Time frame |
|---|---|
| All cause mortality 28 days Incidence rate,Complication due to abnormal bleeding 28 days Incidence rate,Metabolic disturbance ; prolong aPTT, hypoK, hyperHCO3, low serum Ca 28 days Incidence rate | — |
Countries
Thailand
Contacts
Public ContactChotaya Kaewsangsai
Vajira hospital, Navamindradhiraj university
Outcome results
None listed