Hypocalcemia,
Conditions
Interventions
regional citrate anticoagulation can successfully anticoagulated a hemodialysis circuit ,25 to 30 mL of saline flushes are administered every 15 to 30 minutes into the arterial (pre-
dialyzer) limb to minimize hemoconcentration and to wash out fibrin clots into the bubble trap.
Experimental Drug,Active Comparator Drug
regional citrate anticoagulation,routine saline flushing
Sponsors
Government
Government
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients were eligible for enrollment if they were aged 18Â years or older Patients with AKI requiring RRT, acute intermittent hemodialysis Contraindication to systemic anticoagulation or medium-to high bleeding risk during hemodialysis Informed consent
Exclusion criteria
Exclusion criteria: Patients were treated with antiplatelet ,oral anticoagulant therapy or other drugs known to affect coagulation within 7 days Acute liver failure or DIC Abnormal plasma total calcium < 7.0 mg/dL Documented arrhythmia Known allergy to citrate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dialyzer clotting 30, 60, 120,240 min after start regional citrate infusions Number of dialyzer clotting | — |
Secondary
| Measure | Time frame |
|---|---|
| Circuit survival time Time to first event of dialyzer clotting minute | — |
Countries
Thailand
Contacts
Public ContactSirorat Waraaswapati
Bhumibol Adulyadej Hospital
Outcome results
None listed