Perioperative versus Postoperative Oral Calcium and Vitamin D Supplement to Prevent Symptomatic Hypocalcemia after Total Thyroidectomy: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200622005

Enrollment

160

Registered

2020-06-22

Start date

2017-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who underwent total or completion thyroidectomy from June 1st, 2017 to June 30th, 2020 at the department of otolaryngology, Maharaj Nakorn Chiang Mai Hospital Thyroidectomy, Hypocalcemia, Calcium, Vitamin D

Interventions

3 days preoperative intake of Calcium carbonate (1500mg) 1 tab q 8 h Alphacalcidol (0.25mcg) 2 tab q 12 h,3 days preoperative intake of placebo mimicking calcium carbonate and alphacalcidol

Active Comparator Drug,Placebo Comparator Drug

Perioperative calcium and vitamin D,Postoperative placebo

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients who underwent total or completion thyroidectomy

Exclusion criteria

Exclusion criteria: 1. Patients who have parathyroid diseases of hypoparathyroidism preoperatively 2. Abnormal serum calcium (normal range 8.5-10.2 mg/dl) 3. Abnormal serum phosphate (normal range 2.5-4.5 mg/dl) 4. Abnormal serum magnesium (normal range 1.32-2.14 mEq/L) 5. Abnormal creatinine clearance >60 ml/min 6. Abnormal liver function (Total bilirubin >1.5 mg/dl, AST >40 U/L, ALT >41 U/L, alkaline phosphatase >129 U/L) 7. Patients with underlying heart diseases 8. Patients who currently breast feeding or pregnancy 9. Patients who have calcium or vitamin D as current medications

Design outcomes

Primary

Measure	Time frame
symptoms of numbness, Trousseau's sign, Chvostek's sign 1st, 2nd, 3rd, and 14 days after the operation positive/negative symptoms of numbness, positive/negative Trousseau's sign, positive/negativeChvoste	—

Secondary

Measure	Time frame
serum calcium level 1st, 2nd, 3rd, and 14 days after the operation serum calcium (mg/dl)	—

Countries

Thailand

Contacts

Public ContactPichit Sittitrai

Department of Otolaryngology, Faculty of Medicine, Chiang Mai University

psittitrai@yahoo.com6653935564

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026