1.Drug allergy 2.Drug side effects Postoperative pain Wound instillation Anesthetic cocktail Posterior Spinal surgery
Conditions
Interventions
All patients received standard general anesthesia with endotracheal tube of appropriate size. Fentanyl 1-
2 mcg/kg intravenous was administered after induction of anesthesia for intraoperative analgesia. Once the surgical procedure was completed,
hemostasis was secured and radivac drain (without suction) was placed under muscle layer.Patients in group A received 20 ml of anesthetic cocktails for 60 seconds. The anesthetic cocktails is comprise
20 ml),
3 mg morphine sulfate (0.3 ml),
and 30 mg ketorolac (1 ml). These were mixed with sterile normal saline solution to make up a combined volume of 20 ml.Then,
the wound was closed in layers without mopping or suctioning and radivac drain was opened after patient was turned to supine position.Post-
operation,
both groups of patients received intravenous PCA for 24 hours using morphine. The PCA device was set to inject 1 mg in 1 mL (100 mg of morphine in 90 ml normal saline) when patients pressed a button w
minute lockout period. There was no continuous infusion and the maximal dose was limited to 20 mg every 4 hours. In addition to PCA,
Paracetamol 500 mg was administered every 4 hours. Moreover Pethidine 25 mg was intravenous administered for rescue analgesia at every 4 hours when the patient requested or visual analog scale > 3 aft
related side effects were also monitored. In case of vomiting,
Metoclopramide 10 mg was intravenously given at every 8 hours until nausea and vomiting improved. Chlorpheniramine 10 mg maleate was also used intravenously every 6 hours for pruritus. Omeprazole 40 m
Experimental Drug,Placebo Comparator Drug
Group A,Group N
Sponsors
Maha Vajiralongkorn foundation
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Posterior spinal surgery not exceeding 5 levels - Understand and able to use patient-controlled analgesia machine
Exclusion criteria
Exclusion criteria: - Allergy or intolerance to study drugs - Operative complications - Massive Bleeding > 2,000 ml - Dura tear with CSF leakage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy of anesthetic cocktail wound instillation for postoperative anesthesia 24 hous post-operative Morphine consumption, VAS, Time for first demand of morphine | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects of morphine consumption between group 24 hous post-operative Number of Morphine-related side effects (nausea, vomiting and pruritus) | — |
Countries
Thailand
Contacts
Public ContactChayapon Trekajonsak
Bangbo Hospital
Outcome results
None listed