Catheter loss due to CRT or CRBSI Catheter lock Catheter related blood stream infection Catheter related thrombosis End stage renal disease Sodium bicarbonate Heparin
Conditions
Interventions
7.5% sodium bicarbonate lock permanent catheter every hemodialysis sessions,heparin lock permanent catheter every hemodialysis sessions
Experimental Drug,Active Comparator Drug
7.5% sodium bicarbonate,heparin
Sponsors
Grant for research, Faculty of medicine, Chulalongkorn university
The kidney foundation of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients age more than 18 years old 2. Patients with maintenance chronic hemodialysis at least 2 sessions per week 3. Patients with permanent catheter as vascular access for hemodialysis
Exclusion criteria
Exclusion criteria: 1. Catheter dysfunction at baseline 2. On current anticoagulation therapy 3. Patients with known coagulopathy or hemophilia 4. Patients with cirrhosis Child-Pugh B or C 5. Patients with thrombocytopenia less than 100,000 u/L 6. Patients with central vessel stenosis and vena cava syndrome, previously documented. 7. Patients with heparin-induced thrombocytopenia 8. Patients with unstable condition within 1 month before enrollment 9. Patients with expected life expectancy less than 6 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Catheter loss rate due to CRBSI and CRT 0, 3, 6 months record events per 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Composite outcome of CRT, CRBSI, or ESI/TI rate 0, 3, 6 month percentage | — |
Countries
Thailand
Contacts
Public ContactWannasit Wathanavasin
Division of nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed