Intradialytic hypertension Intradialytic hypertension Spironolactone Mineralocorticoid receptor antagonist
Conditions
Interventions
Patients in intervention arm will be prescribed 2 tablets (50 mg) of spironolactone 30 minutes prior to undergo hemodialysis in every sessions during study period.,Patients in controlled arm will unde
Experimental Drug,No Intervention No treatment
Spironolactone,No intervention
Sponsors
Lampang hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. ESRD patients (defined by Kidney Disease Initiative Global Outcome (KDIGO) Guideline 2012) requiring chronic hemodialysis 2. Hemodialysis vintage more than 12 weeks 3. Hemodialysis with at least 2 sessions per week 4. History of intradialytic hypertension (defined by an increase in systolic blood pressure >15 mmHg or mean arterial pressure >10 mmHg during hemodialysis) at least 30% of their dialysis sessions during the past 12 weeks
Exclusion criteria
Exclusion criteria: 1. Serum potassium >5.5 mEq/L or <2.5 mEq/L 2. Active cardiac, pulmonary or hepatobiliary tract disease 3. Active infection or sepsis 4. Active malignancy 5. Cirrhosis 6. Prior treatment with spironolactone in past 4 weeks 7. Contraindication to spironolactone 8. Interdialytic weight gain more than 6%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intradialytic hypertension 24-week study period Proportion of intradialytic hypertension (%) | — |
Secondary
| Measure | Time frame |
|---|---|
| Intradialytic blood pressure 24-week study period Blood pressure (mmHg),Serum potassium End of study mEq/L,Pre-dialysis blood pressure 24-week study period Blood pressure (mmHg),Post-dialysis blood pressure 24-week study period Blood pressure (mmHg),Prespecified subgroup analyses of the primary outcome 24-week study period diabetes, receiving ACEI/ARB, receiving more than three anti-hypertensive medications and the presence of residual kidney function (RKF),Peak intradialytic blood pressure 24-week study period Blood pressure (mmHg) | — |
Countries
Thailand
Contacts
Public ContactThanawat Vongchaiudomchoke
Department of internal medicine, Lampang hospital
Outcome results
None listed