Hepatocellular carcinoma in type 2 diabetes with cirrhosis. Hepatocellular carcinoma type 2 diabetes cirrhosis
Conditions
Interventions
The continuous exposure of Metformin at least 3 months.,The continuous exposure of Metformin less 3 months.
Other,Other
Metformin exposure group,Metformin non-
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Faculty of Medicine Siriraj Hospital,
Mahidol University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) patients had to be 20-80 years old 2) Diagnosed with T2D Using diagnostic criteria From the American Diabetes Association, (ADA) or self-reported medical history or physician note even or taking anti diabetic agents 3) the diagnosis of cirrhosis was diagnosed by histology or clinical features or radiological images 4) T2D was diagnosed before the onset of cirrhosis and HCC 5) T2D has been newly diagnosed with cirrhosis of various causes in the period from 2006-2014.
Exclusion criteria
Exclusion criteria: 1) patients who underwent liver transplantation 2) patients were follow up at Siriraj hospital less than 5 years 3) diagnosis of cirrhosis along with HCC or diagnosed with HCC after diagnosis of cirrhosis in less than 1 year 4) incomplete clinical information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of HCC in Type 2 DM with cirrhosis who were treated with Metformin 5 years after diagnosed with cirrhosis incidence of HCC patients | — |
Secondary
| Measure | Time frame |
|---|---|
| The median survival of the HCC patients with Metformin exposure group Death 5-year survival rate, kaplan meier method | — |
Contacts
Public ContactTada Kunavisarut
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed