Gastrointestinal hemorrhage is a precipitating cause of hepatic encephalopathy in cirrhosis patients. Lactulose is frist line theraphy of hepatic encephalopathy. Can lactulose prevent hepatic encephal hepatic encephalopathy lactulose cirrhosis upper gastrointestinal bleeding prevention prophylaxis
Conditions
Interventions
Lactulose oral 30 ml three times per day or hold if patient developed loose stool at least 3 time per day.,syrup oral 30 ml three times per day or hold if patient developed loose stool at least 3 time
Experimental Drug,No Intervention No treatment
Lactulose,placebo
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: cirrhotic patients presenting with upper gastrointestinal bleeding who underwent esophagograstroduodenoscopy within 24 hours after symptom presentation.
Exclusion criteria
Exclusion criteria: 1. underlying disease of neurological disease 2. presence of hepatic encephalopathy at the time of admission 3. history of lactulose usage within 6 weeks before 4. severe co-morbidity such as acute kidney injury, active cardiopulmonary disease 5. history of alcohol ingestion within 7 days before
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hepatic encephalopathy day 5 incidence of hepatic encepalopathy according to west haven criteria grade 3 or more | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospitalization form admission to discharge days | — |
Countries
thailand
Contacts
Public ContactAttapon Rattanasupa
Hatyai Hospital
Outcome results
None listed