Healthy Healthy volunteers
Conditions
Interventions
Trimethoprim-sulfamethoxazole is antibiotics commonly used in renal transplant recipients for pneumococcal pneumonia prophylaxis.
Experimental Drug
Trimethoprim-sulfamethoxazole
Sponsors
Faculty of Medicine, Chiang Mai University
Faculty of Medicine,
Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers aged between 18-40 years with a creatinine clearance of >90 mL/min, ALT of <40 IU/L, AST of <35 IU/L, and serum albumin of >3.5 g/L.
Exclusion criteria
Exclusion criteria: Known contraindication or hypersensitivity to mycophenolate mofetil, trimethoprim-sulfamethoxazole and other sulfa agents, such as sulfonamide or probenecid; known or suspected pregnancy or breast-feeding; chronic liver disease; hematological disorder; immunocompromised condition; taking antibiotics within 3 months prior to enrollment; regular consumption of alcohol, cigarette smoking, or recreational drugs use/addition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters 0-48 hours HPLC | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety parameters Until the end of study Physical examination and laboratory assessments,Genetic variants Day 0 Sequencing,Microbiota Day 0, Day 9, Day 14 Sequencing | — |
Countries
Thailand
Contacts
Public ContactNut Koonrungsesomboon
Faculty of Medicine, Chiang Mai University
Outcome results
None listed