Oral lichen planus Tissue resident memory T cells Oral lichen planus CD103
Conditions
Interventions
The OLP specimens retrieved from 15 paraffin-
embedded tissue blocks ,The normal mucosa tissues were taken from 15 healthy normal subjects who were undergoing third molar surgical removal
Basic Science,Basic Science
Oral lichen planus ,็Healthy normal
Sponsors
Faculty of Dentistry, Chulalongkorn University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Clinical features showed the bilateral white striae with atrophic and/or ulcerative/erosive lesions. 2) Histopathological features showed the lymphocytic band confined to the superficial lamina propria and signs of the liquefactive degeneration in the basal layer of the epithelium with absence of epithelial dysplasia.
Exclusion criteria
Exclusion criteria: 1) Lesions associated with an amalgam filling and/or a metal crown restoration. 2) Patients had known history of systemic diseases and/or medication taking. 3) Patients received topical corticosteroid therapy for the lesions in the last 1 month prior to biopsies. 4) Patients were pregnant women, alcohol drinkers and/or smokers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numbers of CD103+ Tissue resident memory T cells at 6 months after recruitment of specimens cell counting using ImageJ | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportions of CD103+ Tissue resident memory T cells to CD3+ T cells at 6 months after recruitment of specimens cell counting using ImageJ | — |
Countries
Thailand
Contacts
Public ContactPornpan Piboonratanakit
Chulalongkorn University
Outcome results
None listed