Pregnant women with GDM typically have different levels of insulin resistance and chronic low-
Conditions
Interventions
Each woman in the intervention group will be given Metformin (500 mg) 1 tablet oral once a day since 30 to 32 weeks’ gestation throughout the entire study period.,For the control group,
each woman will be given placebo 1 tablet oral once a day. The placebo was produced from Faculty of Pharmacy,
Chiang Mai University
Experimental Drug,Placebo Comparator Drug
Metformin,Placebo
Sponsors
None listed
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Women undergoing antenatal care and vaginal delivery at Maharaj Nakorn Chiang Mai Hospital (Faculty of Medicine, Chiang Mai University) 2. Age 20-45 years 3. The patients with gestational diabetes mellitus (GDM) diagnosed based on the National Diabetes Data Group (NDDG) criteria since 20 weeks’ gestation. 4. All women with GDM had normal medical histories before pregnancy
Exclusion criteria
Exclusion criteria: 1. Patients with GDM whose blood glucose was poor controlled which need insulin therapy 2. Women with systemic diseases such as hypertension, heart disease, renal disease, connective tissue disease, hepatic disease 3. Women with twin pregnancy, major structural fetal anomaly, pregnancy-induced hypertension, and preterm labor in this pregnancy 4. Poor obstetric history requiring medication during gestation eg. recurrent pregnancy loss, previous occurrence of pre-eclampsia, preterm labor, intrauterine growth restriction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean platelet volume (MPV) In third trimester of pregnancy and intrapartum A peripheral venous blood sample, to measure complete blood count (CBC) parameters ,The blood clotting time of pregnant woman Intrapartum The whole blood clotting test,The estimate blood loss after vaginal delivery During vaginal delivery Postpartum blood loss collected via a plastic scale collecting bag | — |
Secondary
| Measure | Time frame |
|---|---|
| The clotting time of cord blood During vaginal delivery The whole blood clotting test,Post-vaginal delivery complications Postpartum Post-vaginal delivery complications | — |
Countries
Thailand
Contacts
Public ContactPanisa Hantrakun
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University
Outcome results
None listed