Patients undergoing elective benign open abdominal gynecological surgery intravenous acetaminophen acetaminophen abdominal gynecological surgery hysterectomy postoperative pain benign gynecological surgery
Conditions
Interventions
Each patient receives intravenous acetaminophen 15 mg/kg if less than 50 kg or 1000 mg if ≥ 50 kg. The first dose is given 30 minutes before surgery,
then three doses are given every 6 hours after the first dose.,The patient receives 100 ml of normal saline solution (NSS) intravenously instead of acetaminophen.
Experimental Drug,Placebo Comparator No treatment
acetaminophen group (A group),Placebo group (N group)
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 18-65 years old 2. Patients who undergoing elective benign open abdominal gynecological surgery 3. American Society of Anesthesiologists (ASA) Class I-III
Exclusion criteria
Exclusion criteria: 1. Patients with known allergy to acetaminophen, parecoxib, sulfonamides, aspirin or opioids 2. Patients with either acute or chronic liver disease (defined as abnormal rising AST ALT, hypoalbuminemia, prolonged INR, or evidence from imaging diagnosis) 3. Patients with moderate to severe pain before surgery 4. Third trimester pregnant patients or lactation period 5. Patients receive any additional neuraxial block or peripheral nerve blocks for pain control 6. Patients with history of opioid abuse or chronic opioid use for greater than 3 months 7. Patients with suspected malignant gynecological disease intraoperatively and undergo extended lymph node dissection or complete surgical staging 8. Patients with contraindication to parecoxib (post CABG surgery, established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease, inflammatory bowel disease, Child-Pugh score ≥ 10, active peptic ulcer/ GI bleeding, known hypersensitivity to sulfonamides)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative postoperative morphine consumption within 24 hours 24 hours of postoperative Morphine consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay between two groups during hospitalization length of hospital stay,time to first flatulence and first defecation after surgery between two groups during hospitalization time to first flatulence and first defecation,time to first ambulation between two groups time to first ambulation time to first ambulation,Time to first dose morphine requirement time to first dose morphine time to first dose morphine,Adverse effects of acetaminophen, morphine, parecoxib during hospitalization patient report, observation,Postoperative pain at rest 1,4,8,12,16,20,24,48 hours postoperatively Numeric rating scale | — |
Countries
Thailand
Contacts
Public ContactTanthip Jiruttikarnsakul
Faculty of Medicine, Chiang Mai University
Outcome results
None listed