Dose the comparison of different regimens of intravenous tranexamic acid can reduce blood transfusion in femoral neck fracture after hip hemiarthroplasty ? hip hemiarthroplasty,
Conditions
Interventions
Tranexamic acid 750 mg IV bolus dose prior to skin incision
then tranexamic acid 750 mg next 3 hr
,Tranexamic acid 750 mg IV bolus dose prior to skin incision
then NSS 20 ml next 3 hr
double dose Tranexamic acid,single dose Tranexamic acid,placebo
Sponsors
Department Orthopedic Surgery, Mahidol University Faculty of Medicine Siriraj Hospita
Research Unit Department Orthopedic Surgery,
Mahidol University Faculty of Medicine Siriraj Hospita
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged older than 60 years undergoing primary hip hemiarthroplasty for fracture neck of femur
Exclusion criteria
Exclusion criteria: - high energy trauma - pathological fracture - contraindication for tranexamic acid - accidentally intraoperative fracture require revision femoral stem - acetabulum pathology require covert to total hip arthroplasty - bleeding disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood transfusion given perioperative and post operative day1-2 CBC | — |
Secondary
| Measure | Time frame |
|---|---|
| Transfusion unit perioperative and post operative day1-2 CBC ,Intraoperative blood loss perioperative intraoperative blood loss by suction,Delta hemoglobin perioperative and post operative day1-2 CBC ,Total blood loss in 24,48 hr post operative day1-2 CBC ,Length of stay admision Length of stay,Postoperative complication admision, follow post op 2,6,12 weeks complication | — |
Countries
Thailand.
Contacts
Public ContactChaturong Pornrattanamaneewong
Department Orthopedic Surgery
Outcome results
None listed