Efficacy of Biphasic Calcium phosphate and Platelet Rich Fibrin in socket preservation

Alveolar-ridge-preservation capability of nano biphasic calcium phosphate (50:50 ratio) compared to freeze-dried bone allograft in extraction socket sealed with PRF membrane: A randomised controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200503002

Enrollment

Unknown

Registered

2020-05-03

Start date

2015-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who underwent extraction of the single&#45

Interventions

Socket graft with FDBA and seal socket orifice with platelet&#45

rich fibrin membrane (PRF membrane),Socket graft with BCP and seal socket orifice with platelet&#45

rich fibrin membrane (PRF membrane)

Experimental Procedure/Surgery,Experimental Procedure/Surgery

freeze&#45

dried bone allograft (FDBA),biphasic calcium phosphate (BCP)

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: single tooth extraction and later dental implant placement and the extracted teeth were bounded by adjacent teeth

Exclusion criteria

Exclusion criteria: Patients who were smokers, metabolic bone disease, pregnancy,history of malignancy or radiotherapy or chemotherapy for malignancy in the past 5 years ; history of autoimmune disease and long-term steroidal or antibiotic and sign of any active infection and not able to follow instructions related to the study procedures.60

Design outcomes

Primary

Measure	Time frame
dimensional change 2,6,8,12 week cast-based measurement, cone beam computed tomography(CBCT)	—

Secondary

Measure	Time frame
new bone formation 2,6,8,12 week Micro-CT, Histomorphometric	—

Countries

Thailand

Contacts

Public ContactPrisana Pripatnanont

Prince of Songkla University

prisana.p@psu.ac.th0813686306

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026