Obesity and obesity related parameters obesity,
Conditions
Interventions
A starch capsule was given to subjects twice a day after breakfast and dinner for 8 weeks with no dietary restriction.,A capsule of 300 mg Cissus Quadrangularis(CQ)extract was given to subjects twice
Placebo,Cissus Quadrangularis (CQ) extract,Epigallocatechin gallate (EGCG)
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
The Thailand Research Fund (TRF) through the Royal Golden Jubilee Ph.D. Program
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Thai obese subjects, BMI ≥ 25 kg/m2 and age > 18 years, were recruited.
Exclusion criteria
Exclusion criteria: Subjects who were pregnant, lactating, menopause; had metabolic diseases (e.g. diabetes mellitus, hyper- or hypo-thyroidism, cushing syndrome), history of tea or caffeine hypersensitivity, a medical condition that causes weight gain known as secondary obesity (e.g. endocrine disorders, hypothalamic disorders, and some congenital conditions); used any forms of weight-reducing medications or any kinds of medications; and performed regular exercise (at least 30 min/session, 3 times per week48) were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body weight and BMI 0, 4, and 8 weeks of treatments Kg and kg/m2,waist and hip circumferences 0, 4, and 8 weeks of treatments cm | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure 0, 4, and 8 weeks of treatments mmHg,Blood leptin, kisspeptin, and adiponectin levels 0, 4, and 8 weeks of treatments ng/ml,heart rate/heart rate variability (HRV) 0, 4, and 8 weeks of treatments beats/minute,fasting plasma insulin, triglyceride, total cholesterol, high-density lipoprotein (HDL) cholesterol, 0 and 8 weeks of treatments mg/dL,blood urea nitrogen (BUN), creatinine, and estimated glomerular filtration rate (eGFR) 0 and 8 weeks of treatments mg/dL,total bilirubin, direct bilirubin, aspartate aminotransferase, and alanine aminotransferase 0 and 8 weeks of treatments mg/dL | — |
Countries
Thailand
Contacts
Public ContactChantacha Sitticharoon
Faculty of Medicine Siriraj Hospital
Outcome results
None listed