Gastroesophageal Reflux symptom
Conditions
Interventions
intervention group received proton pump inhibitor (PPI) plus baclofen 0.25 mg per kg two times per day. ,The controls received only proton pump inhibitor 1 mg per kg treatment.
Experimental Drug,No Intervention Drug
intervention group ,control
Sponsors
Golestan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Months to 12 Years
Inclusion criteria
Inclusion criteria: all children aged 6 months to 12 years with GERD who had at least two of the following five symptoms for at least one month. These symptoms included vomiting immediately after feeding, the persistence of reflux symptoms despite other treatments, restlessness after feeding for one to three hours, apnea and respiratory distress after feeding, no weight gain or weight gain of less than 500 grams, or weight loss during the last month and refusal to feed
Exclusion criteria
Exclusion criteria: patients less than 6 months and more than 12 years, patients taking baclofen for reasons other than GERD, patients with a history of anti-reflux surgery, patients with endoscopic evidence of Helicobacter pylori gastritis or eosinophilic esophagitis, patients with evidence of gastroparesis radiography and lack of parental consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroesophageal Reflux disease 4 month clinical symptoms of the patients | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastroesophageal Reflux disease 4 month abdominal pain, nausea, retrosternal pain, weight loss, poor appetite, dyspepsia, regurgitation, cou | — |
Countries
iran
Contacts
Public ContactMohammad Sobhani Shahmirzadi
Associate Professor, Pediatric Gastroenterologist, Neonatal and Children’s Health Research Center,
Outcome results
None listed