The Efficacy of 3 different modes of Erbium:YAG 2,940-nm laser combined with Neodymium:YAG 1,064-nm laser for the Lower Eyelid Rejuvenation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200413003

Enrollment

Unknown

Registered

2020-04-13

Start date

2017-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatochalasis Eye Bag Meibomian Gland Dysfunction Lower eyelid rejuvenation Dermatochalasis Laxity Er:YAG Nd:YAG Smooth PIANO Meibomian Gland Dysfunction

Interventions

The 3 different modes of Er:YAG laser (transconjunctival SmoothLiftin&#44

SmoothLiftin and SupErficial) combined with PIANO mode Nd:YAG laser were delivered to every participant for 4 monthly sessions.

Experimental Device

Erbium:YAG laser with Neonymium:YAG laser

Eligibility

Sex/Gender

All

Age

35 Years to No maximum

Inclusion criteria

Inclusion criteria: Volunteers aged 35 years old or older with eye bags

Exclusion criteria

Exclusion criteria: 1. Female volunteers who are currently pregnant or breastfeeding 2. Volunteers who used topical retinoids in the last month 3. Volunteers who received any form of exogenous estrogen in the last month 4. Volunteers who had facial chemical peeling or dermabrasion in the last month 5. Volunteers who took oral isotretinoin in the last 6 months 6. Volunteers who had botulinum toxin treatment in the periorbital area in the last 6 months 7. Volunteers who had HA, collagen or fat filler in the periorbital area in the last 6 months 8. Volunteers who had light/laser, radiofrequency or ultrasound treatment in the periorbital area in the last 6 months 9. Volunteers who had blepharoplasty within the last 6 months 10. Volunteers who had underlying photo-sensitive diseases

Design outcomes

Primary

Measure	Time frame
Pictures Week 0, 4, 8, 12, 16, 24 Digital camera	—

Secondary

Measure	Time frame
Uniqueness Score Week 0, 4, 8, 12, 16, 24 Digital camera,ViscoElasticity Week 0, 4, 8, 12, 16, 24 Cutometer,Melanin Index Week 0, 4, 8, 12, 16, 24 Antera camera,Erythema Index Week 0, 4, 8, 12, 16, 24 Antera camera,Meibomian Gland Dysfunction Week 0,16, 24 OSDI, Meibum quality score, Lipid layer thickness, Tear-break-up time, ocular surface staining	—

Countries

Thailand

Contacts

Public ContactRatchathorn Panchaprateep

King Chulalongkorn Memorial Hospital

rpanchaprateep@gmail.com+66898923819

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

The Efficacy of 3 different modes of Erbium:YAG 2&#44;940&#45;nm laser combined with Neodymium:YAG 1&#44;064&#45;nm laser for the Lower Eyelid Rejuvenation