Prevention of UVB induced hyperpigmentation UVB hyperpigmentation
Conditions
Interventions
one side of inner arm was randomized 0.15% Isobutylamido thiazolyl resorcinol (ITR) for 3 weeks (week 0)
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3 hyperpigmentary spots induced by local broadband UVB was irradiated at inner arm at week 3,-
one side of inner arm was randomized as a control site (no cream or treatment was applied)
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3 hyperpigmentary spots induced by local broadband UVB was irradiated at inner arm at week 3
Experimental Drug,No Intervention No treatment
Isobutylamido thiazolyl resorcinol (ITR),none
Sponsors
Division of Dermatology, Department of medicine, Faculty of Medicine, Ramathibodi hospital
Beiersdorf (Thailand) Company Limited
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Healthy subjects
Exclusion criteria
Exclusion criteria: -serious underlying conditions -pregnancy or breast feeding -active skin diseases on experimental sites -history of photosensitive disorders -concomitant use of topical medications -previously received laser performing on experimental sites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean lightness index baseline, week 3, week 4, week 5, week 6, week 7 value range from 0 (total black) to 100 (total white); measured using colorimeter | — |
Secondary
| Measure | Time frame |
|---|---|
| hyperpigmentation score by blinded dermatologist baseline, week 3, week 4, week 5, week 6, week 7 evaluated by a blinded dermatologist using visual analogue scale ,hyperpigmentation score by subjects baseline, week 3, week 4, week 5, week 6, week 7 evaluated by a blinded dermatologist using visual analogue scale ,Adverse events at every visit evaluate and record by investigators | — |
Contacts
Public ContactVasanop Vachiramon
Faculty of Medicine, Ramathibodi hospital
Outcome results
None listed