Patients with asymptomatic urinary tract infection undergoing urodynamic study in Srinagarind hospital Antibiotic prophylaxis Asymptomatic urinary tract infection Urodynamic study
Conditions
Interventions
Patients that were assigned to the antibiotic prophylaxis group received a 30-minute intravenous (IV) infusion of gentamicin 5 mg/kg and a 1-hour IV infusion of ampicillin within 1 hour before UDS if
Experimental Drug,No Intervention No treatment
Antibiotic prophylaxis before urodynamic study,without antibiotic prophylaxis before urodynamic study
Sponsors
Faculty of Medicine Research Grant Khon Kaen University
Research Affairs, Faculty of Medicine, Khon Kean University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Patients were admitted for the urodynamic examination 3. no signs and symptoms of UTI, defined according to at least one of the following - fever (temperature over 37.8-Celsius degree) with no other apparent causes - onset of dysuria, urgency, frequency - suprapubic or flank pain - increased spasticity - autonomic dysreflexia - malaise, lethargy, or sense of unease 4. Evidence of pyuria - urine WBC over 10 cells/HPF or -positive urine leukocyte esterase 5. Evidence of significant bacteriuria -bacteria count from urine culture more than 10000 CFU/mL from non-catheter specimens or more than 100 CFU/mL from catheter specimens or positive urine nitrite 6. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Pregnancy and breastfeeding 2. Received any antibiotics 7 days prior to enrollment 3. Known allergy or contraindicated for penicillin, ceftriaxone, or gentamicin 4. Immunocompromised state defined as received immunosuppressive agents, prednisolone more than 15 mg/day or equivalent dose, chemotherapy session in the past 1 month, neutropenia (WBC less than 1000 cells/mm3) 5. Liver cirrhosis child B or C 6. History of urinary stones or bladder outlet obstruction 7. History of urosepsis post-UDS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| An incidence rate of symptomatic UTI assessed within 48 hours after UDS 1 week Assess clinical signs and symptoms of symptomatic UTI combine with urinalysis examination and urine culture within 48 hours after UDS | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects and microbiology clearance of urine at 48 hours after UDS 48 hours Assess clinical adverse effect of antibiotic by questionnaire and performed urine culture at 48 hours after UDS | — |
Countries
Thailand
Contacts
Public ContactSiriluck Anunnatsiri
Faculty of Medicine, Khon Kaen University
Outcome results
None listed