Household members of newly diagnosed COVID-19 patients Household members COVID-19 Prophylaxis
Conditions
Interventions
Chloroquine 10 mg base/kg once a day on Day 1 and Day 8,Vitamin C 1000 mg once a day from Day 1 to Day 14
Experimental Drug,Active Comparator Drug
Chloroquine,Vitamin C
Sponsors
Health Systems Research Institute (HSRI)
Siriraj Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >18 years old at the time of consent 2. Male or female 3. At least one household member diagnosed with COVID-19 by RT-PCR or serology within the past 7 calendar days 4. Has a negative pregnancy test if the subject is female and pre-menopausal 5. Has provided written consent for participation; written consents from both the subject and a legal guardian
Exclusion criteria
Exclusion criteria: 1. Has a RT-PCR test positive for SARS-CoV2 from pharyngeal or nasopharyngeal swab at baseline (they could be enrolled, and exclude later) 2. Abnormal laboratory >= grade 3 3. Pregnant or planning pregnancy 4. HIV patients receiving PI therapy 5. History of glucose-6-phosphate dehydrogenase (G6PD) deficiency 6. Hypersensitivity to 4-aminoquinoline derivatives 7. Deemed ineligible as determined by the principal investigator or a co-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seroconversion of SARS-CoV2 Day 21 Rate of seroconversion | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of hospitalization During 21 day Rate of hospitalization | — |
Countries
Thailand
Contacts
Public ContactSuvimol Niyomnaitham
Faculty of Medicine Siriraj Hospital
Outcome results
None listed