Sorology-
Conditions
Interventions
Patients with serology-
confirmed of dengue infection who had initial SGOT > 350 U/L or SGPT > 400 U/L and later developed acute liver failure according to the AASLD criteria.,Patients with serology-
confirmed of dengue infection who had initial SGOT > 350 U/L or SGPT > 400 U/L but did not develop acute liver failure according to the AASLD criteria.
Diagnostic,Diagnostic
Dengue-
induced severe hepatitis with acute liver failure,Dengue-
induced severe hepatitis without acute liver failure
Sponsors
None
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age > 10 years; (2) Dengue infection and classification were defined according to the WHO criteria7 with serological confirmation by the detection of dengue immunoglobulin M antibody or nonstructural 1 antigen; (3) Blood tests for serum glutamate-oxaloacetate transaminase (SGOT) > 350 U/L or serum glutamate-pyruvate transaminase (SGPT) > 400 U/L within 24 hours after hospital admission.
Exclusion criteria
Exclusion criteria: (1) Liver biochemistries was not performed within 7 days after the onset of fever; (2) Incomplete clinical information; and (3) Having concomitant cause of liver injury, such as the use of acetaminophen with dose over 150 mg/kg within the recent 96 hours; a prior consumption of > 40 (female) or > 60 (male) gram of alcohol/day within the recent 60 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute liver failure from dengue infection 28 days Observation | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality 30 days Observation | — |
Countries
Thailand
Contacts
Public ContactTongluk Teerasarntipan
Chulalongkorn University
Outcome results
None listed