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Alkaline electrolyzed water, regular walking, oxidative stress, inflammation and type 2 diabetes

A clinical study on the oxidative stress and infammation improvement effect of alkaline electrolyzed water in type 2 diabetes patients: a community-based randomized control trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200403002
Enrollment
Unknown
Registered
2020-04-03
Start date
2018-07-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus Type 2 diabetes mellitus

Interventions

The participants in the alkaline electrolyzed water group consumed 2 liters per day of alkaline electrolyzed water with pH 9&#44
5 and oxidative&#45
reduction potential of &#45
400.1± 13.3 mV for eight weeks (Alkaline electrolyzed water is produced from Kangen Water Type SD501 Platinum Machine&#44
Japan and packaged in a dark bottle to maintain the stability of hydrogen as well as fresh alkaline electrolyzed water was prepared twice a week (Gadek et al.&#44
2006&#44
Kajiyama et al.&#44
2008&#44
Li et al.&#44
Ogawa et al.&#44
2019&#44
Siswantoro and Purwanto&#44
2017). The research assistants collected the information report for three days per week and encouraged the participants’ adherence to the intervention. ,The participants in the regular walking group
park or roads&#44
without easured how much distance and speed (Sigal et al.&#44
2018). Self&#45
reported logbooks were provided for the participants to record their frequency and duration of regular walking. The research assistants collected the information weekly and encouraged the participants
5 and to walk at least five times per week for 30 minutes or 150 minutes per week for eight weeks. The research assistants collected the frequency and duration of regular walking report for three days
Experimental Dietary Supplement,Experimental Behavioral,Experimental Behavioral,Placebo Comparator Behavioral

Sponsors

Ministry of Science and Technology, Taiwan (MOST)
Lead Sponsor
Ministry of Science and Technology&#44
Collaborator
Taiwan (MOST)
Collaborator

Eligibility

Sex/Gender
All
Age
17 Years to 79 Years

Inclusion criteria

Inclusion criteria: The inclusion criterias were (1) Indonesian nationals aged 17–79 years, (2) those who agreed to participate in the study, (3) those who visited the outpatient a community clinic and completed the questionnaires, and (4) those who had received diagnose of type 2 diabetes mellitus confirmed by the physician with 2-hours plasma glucose test results > 200 mg/dL or fasting plasma glucose > 126 mg/dL

Exclusion criteria

Exclusion criteria: Participants who (1) had an experience of drinking alkaline electrolyzed water, (2) had Mini-Mental State Exam scores ≤ 24, (2) had limb amputation or could not walk, (3) were pregnant, (4) used antidepressants, and (5) had auditory deficiencies were excluded from the study.

Design outcomes

Primary

MeasureTime frame
Oxidative stress at 8 weeks after end of the intervention advanced glycation end products, advanced oxidation protein products, and malondialdehyde using enzy,Inflammatory at 8 weeks after end of the intervention neutrophil-lymphocyte ratio, and white blood cells using ELISA

Secondary

MeasureTime frame
Quality of Life at 8 weeks after end of the intervention The 36-Item Short Form Survey (SF-36)

Countries

Indonesia

Contacts

Public ContactHsiu-Ting Tsai

Taipei Medical university

hsiuting@tmu.edu.tw+886-2-2736-1661

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026