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Evaluation of the effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress using thiol–disulfide balance and C-reactive protein levels: a randomized trial

Evaluation of the effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress using thiol–disulfide balance and C-reactive protein levels in patients undergoing shoulder arthroscopy: a randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200329001
Enrollment
Unknown
Registered
2020-03-29
Start date
2018-02-28
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing shoulder surgery Arthroscopy

Interventions

Ultrasound guided interscalene brachial plexus block by 20 mL of 0.25% bupivacaine + 1% lidocaine by a 50&#45
mm 22G nerve block needle 40 minutes before the surgery,general anesthesia with propofol&#44
fentanyl and rocuronium induction
followed by sevoflurane and remifentanil anesthesia
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
guided interscalene block,general anesthesia

Sponsors

none
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: patients scheduled to undergo shoulder arthroscopy were those who presented to the Orthopedics and Traumatology Outpatient Clinics of our hospital with a complaint of shoulder pain and who remained unresponsive to conservative therapies after being diagnosed with subacromial impingement syndrome.

Exclusion criteria

Exclusion criteria: ; those allergic to the medications used in the present study; those who were obese (body mass index [BMI] > 35 kg/m2); those with an infection at the injection site; those who underwent surgical intervention or had anatomical deformation at the relevant site; those receiving antithrombotic therapy and thus having changes in coagulation parameters; those with severe pulmonary disease, phrenic nerve palsy, diaphragm paralysis, pneumothorax, or neurological dysfunction in upper extremities; those who have received or are currently receiving psychiatric therapy; those receiving opioid therapy for a long period; those with known alcohol and/or drug addiction; those with diabetes mellitus, rheumatoid arthritis, chronic kidney failure, liver diseases, cardiac insufficiency, or Alzheimer’s disease; oncology patients; those who did not accept the relevant anesthesia method after randomization; and those with pathologies such as labral lesions, recurrent instability, or rotator cuff rupture requiring arthroscopic procedure in addition to subacromial decompression

Design outcomes

Primary

MeasureTime frame
oxidative stress intreoperative and postoperative 18 hours thiol–disulfide balance and C-reactive protein

Secondary

MeasureTime frame
pain in postoperative 18 hours visual analgue scale

Contacts

Public ContactMurat Öksüz

Fatih Sultan Mehmet Health Application and Research Center

oksuzmurat@hotmail.com+905547190799

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026