We exclude patients who have a history of asthma,
Conditions
Interventions
They will treat by dexamethasone 4 mg intravenous q6hr for 24hr then three-
day vs five-
day oral prednisolone according to tracking number by Intervention group received 0.5 mg. per kilogram of oral prednisone daily for three days,
followed by placebo for two-
days.,Control Group received 0.5 mg. per kilogram of oral prednisone daily for five days.
Placebo Comparator Drug,Active Comparator Drug
Prednisolone,Prednisolone
Sponsors
khon kaen hospital
kamalasai hospital
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Thai patients who were 20-year-old or older who diagnosed acute exacerbation of COPD and history of the ratio of FEV1 to forced vital capacity (FVC) lower than 70% as evaluated by postbronchodilator spirometry, history of FEV1 lower than 80% as evaluated by postbronchodilator spirometry and smoking history of 10 pack-years or more.
Exclusion criteria
Exclusion criteria: We exclude patients who have a history of asthma, ischemic heart disease, radiological diagnosis of pneumonia, congestive heart failure or other lung diseases, history of any cancer disease, pregnancy or lactation, need continuous immunosuppressive (e.g. prednisolone, dexamethasone, methylprednisolone, IVIG), need a ventilator, inability to follow up and inability to give written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| relapse of acute exacerbation in chronic obstructive pulmonary disease 1 month yes or no of relapse | — |
Secondary
| Measure | Time frame |
|---|---|
| oxygen saturation 1 month pulse oxymeter,failure treatment 1 month count number,symptom's free days 1 month count number,FEV1 1 month spirometer | — |
Countries
thailand
Contacts
Public ContactPotcharapol Samart
Khon kaen hospital
Outcome results
None listed