Comparing ondansetron and placebo for the reduction of spinal anesthesia-induced hypotension, a double blind randomized control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200327001

Enrollment

110

Registered

2020-03-27

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension Bradycardia Hypotension Bradycardia Ondansetron 5&#45

Interventions

ondansetron 8 mg

Placebo Comparator Drug

ondansetron

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 18-65 2.Patients of American Society of Anesthesiologists (ASA) physical status, I or II scheduled for elective urologic, orthopedic or gynecologic surgeries under spinal anesthesia

Exclusion criteria

Exclusion criteria: 1.Refused to participate in the research 2.Emergency case 3.Contraindication for spinal block 4.Allergic to ondansetron and local anesthetic drugs 5.Patients with these underlying diseases (hypertension, heart disease, kidney disease, liver disease, neurological and brain disease). 6.History of serotonin drug used 7.Language barrier 8.Pregnancy

Design outcomes

Primary

Measure	Time frame
Hypotension every 3 minutes until 30 minutes after spinal block Mean arterial pressure decrease > 20% from baseline	—

Secondary

Measure	Time frame
Bradycardia every 3 minutes until 30 minutes after spinal block less than 45 beats per minutes	—

Countries

Thailand

Contacts

Public ContactNuttanun Meekaew

PHRAMONGKUTKLAO HOSPITAL

m_nuttanun@hotmail.com085-331-7592

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

Comparing ondansetron and placebo for the reduction of spinal anesthesia&#45;induced hypotension&#44; a double blind randomized control trial