FindTrial
Sign In

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy Pain Management and the Improvement of Enhanced Recovery After Surgery (ERAS): A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200322003
Enrollment
72
Registered
2020-03-22
Start date
2020-09-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung mass lung mass video&#45

Interventions

Nefopam group: nefopam 20 mg during surgery and follow by 80 mg in 24 hours postoperative,Placebo group: normal saline solution during surgery and follow by normal saline solution drip in 24 hours pos
Experimental Drug,Placebo Comparator Drug
nefopam group,placebo group

Sponsors

Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Schedule to video-assisted thoracoscopic surgery : VATs lobectomy Can operate a patient-controlled analgesia (PCA) device No contraindication for nefopam

Exclusion criteria

Exclusion criteria: Epilepsy&#44; on monoamine oxidase (MAO) inhibitors&#44; glaucoma Creatinine clearance < 60 ml/min Liver disease: child&#45;pugh score B or C Allergy to nefopam Chronic opioid use

Design outcomes

Primary

MeasureTime frame
morphine consumption in first 24 hours post&#45;operative 24 hours morphine consumption record from patient&#45;controlled analgesia machine in 24 hours post&#45;operative—

Secondary

MeasureTime frame
numeric pain score 24 hours numeric pain score in 1&#44; 2&#44; 12&#44; 24 hours after surgery—

Countries

Thailand

Contacts

Public ContactChaowanan Khamtuikrua

Faculty of Medicine Siriraj Hospital&#44; Mahidol University

ckhamtuicrua@gmail.com+6624197990

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026