Major depressive disorder in chronic kidney disease Major depressive disorders,
Conditions
Interventions
Sertraline,
a standard antidepressant for CKD patients in Thai depression guideline,Agomelatine,
a novel antidepressant
Active Comparator Drug,Experimental Drug
Sertraline,Agomelatine
Sponsors
Phramongkutklao Hospital
Phramongkutklao Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. CKD stage 3 – 5 2. Diagnosed MDD by psychiatrist 3 Age ≥ 18 years 4. Performed PHQ-9 score ≥ 7 . Performed Thai HRSD ≥ 8 6. Give written an informed consent
Exclusion criteria
Exclusion criteria: 1. Previous diagnosed with depressive disorders & other psychiatric disorders (Esp. Schizophrenia, Bipolar disorder) 2. History of previous antidepressants treatment 3. Severe depression who needs hospitalization 4. Used the following of drugs : Fluvoxamine, MAO inhibitors, Pimozide, Cimethidine, Ciprofloxacin, Ticlopidine, anti-arrhythmic drug 1C, anti-epileptic drugs, Tramadol, Tryptophan, St. John’s wort 5. History of allergy to Agomelatine & Sertraline 6. Patients in comatose or emergency state 7. History of previous kidney transplantation 8. Medical history of COPD, Alzheimer’s dz, end stage of malignancy 9. History of alcoholism or substance used 10. Liver enzyme impairment 3-fold increased 11. Pregnant or breast feeding woman 12. Suicide score (PHQ-8) ≥ 17
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of depression score 8 weeks Thai HRSD | — |
Secondary
| Measure | Time frame |
|---|---|
| Responsiveness of antidepressant 8 weeks Change of Thai HRSD > 50%,Remission of depression 8 weeks Thai HRSD score < 8,Remission of depression 8 weeks Thai HRSD score < 8,Change of PHQ-9 8 weeks PHQ-9 score,Quality of life 8 weeks WHOQoL BREF THAI | — |
Countries
Thailand
Contacts
Public ContactFadhil Saleh-arong
Phramongkutklao Hospital
Outcome results
None listed