Allergic rhinitis in adult allergic rhinitis,
Conditions
Interventions
isotonic saline nasal spray,3% hypertonic saline nasal spray
Active Comparator Drug,Active Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Faculty of Medicine Siriraj Hospital,
Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) age 18-60 years, (2) diagnosed AR from history, physical examination and positive skin prick test, intradermal test or specific IgE, (3) congestion score from TNSS ≥ 2 at this visit and VAS of congestion > 4 at this visit
Exclusion criteria
Exclusion criteria: (1) nasal anatomic defects such as moderate to severe deviated nasal septum18, nasal polyp or tumor, (2) mucociliary clearance defects such as cystic fibrosis, (3) history of sinonasal surgery, (4) upper or lower respiratory tract infection in the preceding 1 week, (5) active smoker, (6) use of systemic steroid, oral/topical decongestant or antihypertensive drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal congestion symptom pre-dose, at 5 and 15 minute post-dose total nasal symptom score, visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| peak nasal inspiratory flow, nasal airway resistant pre-dose, at 5 and 15 minute post-dose nasal flow meter, rhinomanometry | — |
Countries
Thailand
Contacts
Public ContactThanakrit Wannarong
Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University.
Outcome results
None listed