Benefits to community and social organizations: If found that APRI and FIB-
Conditions
Interventions
Patients with chronic hepatitis from hepatitis B virus (HBV) infection,
hepatitis C virus (HCV) infection,
NAFLD,
and alcoholic liver disease (ALD) who underwent LSM using transient elastography in 11 participated centers in Thailand.
Diagnostic
Chronic hepatitis patients who require hepatic fibrosis assessment
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who underwent successful LSM using TE (from transient elastography database) in 11 participated centers from January 1st, 2009 – August 31st, 2017 whose indications of fibrosis assessment were one of the following; 1)Chronic HBV infection (CHB): defined as HBsAg+ for at least six months, who were not treated with antiviral agent(s) or interferon treatment at the time of LSM. 2)Chronic HCV infection (CHC): defined as antiHCV+ and detectable viremia by HCV RNA, who were not treated with Peginterferon+Ribavirin or direct antiviral agents (DAA) at the time of LSM. 3)NAFLD: defined as hepatic steatosis detected by imaging and/or evidence of steatohepatitis from liver histology plus history of alcohol intake <20 gm/day and HBsAg- antiHCV-
Exclusion criteria
Exclusion criteria: 1) Chronic hepatitis patients from other causes other than CHB, CHC, and NAFLD as described above 2) Patients with co-infection with human immunodeficiency virus (HIV), or HBV/HCV co-infection 3) No available laboratory results of AST, ALT, platelet level within 3 months of LSM 4) Patients with coexisted diseases of either active hemolysis at time of AST/ALT measurement, immune mediated thrombocytopenia, or hematologic malignancies 5) Patients with AST or ALT > 5 times above ULN 6) The subsequent TE measurement(s) in the same patients after the first enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fibrosis stage 3 year Outcome measurement is fibrosis stage using TE as reference standard, which were validated in numero | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactWattana Sukeepaisarnjaroen
Khonkaen University
Outcome results
None listed