Comparison lactate clearance between high dose and conventional dose of Meropenem in sepsis patients Emergency Department; Post-HOC analysis of a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200311001

Enrollment

Unknown

Registered

2020-03-11

Start date

2017-12-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lactate clearance sepsis sepsis high dose meropenam conventional dose meropenam emergency department

Interventions

conventional dose meropenem (the standard&#45

dose group&#44

1 gram of meropenem IV infused over 30 minutes&#44

then 1 g of meropenem IV infused over 3 hours every 8 hours),the high&#45

2 grams of meropenem intravenous (IV) infused over 30 minutes then 2 g of meropenem IV infused over 3 hours every 8 hours

Experimental Drug,Experimental Drug

Meropenem dose 1 gram,Meropenem dose 2 grams

Eligibility

Sex/Gender

All

Age

18 Years to 110 Years

Inclusion criteria

Inclusion criteria: 1) patients aged â‰¥ 18 years 2) patients who diagnosed as sepsis and septic shock according to sepsis-3 criteria 3) patients were receiving Meropenem as empirical eligible for enrollment

Exclusion criteria

Exclusion criteria: 1) patients receiving Meropenem within 7 day before enrollment, 2) patients requiring operations within 72 hours after enrollment 3) patients having known allergy or had contraindication to Meropenem 4) patients who receiving Extracorporeal membrane oxygenation 5) patients who having sepsis with central nervous system infection, infective endocarditis or osteomyelitis, 6) patients with active seizure or status epilepticus 7) patients who receiving cardiopulmonary resuscitation before enrollment

Design outcomes

Primary

Measure	Time frame
lactate clearance at 6 hours 6 hours met the one of two criteria 1) lactate clearance >10% at 6 hours (compare initial lactate level to l	—

Secondary

Measure	Time frame
lactate clearance at day 3 day 3 met the one of two criteria 1) lactate clearance >10% at day 3 (compare initial lactate level to lac,30-day mortality day 30 n (%),30-day hospital free day day 30 day alive without hospitalization (day),vasopressor used day 7 n (%),acute kidney injury; KDIGO stage at day3 and day7 day 3, day 7 n (%)	—

Countries

Thailand

Contacts

Public Contactpitsucha sanguanwit

viratch@yahoo.com

mejijung@yahoo.com+66841300301

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026

Comparison lactate clearance between high dose and conventional dose of Meropenem in sepsis patients Emergency Department; Post&#45;HOC analysis of a randomized controlled trial