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Comparison of intubation rate between High flow nasal cannula versus Non -invasive positive pressure ventilation in acute hypoxic respiratory failure among immunocompromised patients in Emergency department

Comparison of intubation rate between High flow nasal cannula versus Non -invasive positive pressure ventilation in acute hypoxic respiratory failure among immunocompromised patients in Emergency department

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200309002
Enrollment
130
Registered
2020-03-09
Start date
2019-12-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Can High flow nasal cannula decrease Intubation rate than Non&#45

Interventions

Initial setting FiO2 =0.4&#45
1.0 Flow = 50L/min Keep O2 sat 92&#45
95% follow up ABG 1 hr. and clinical then weaning setting decrease FiO2 0.2/hr. until Fio2 0.4 Keep O2 sat 92&#45
95% ABG 2 hr. later Oxygen cannula 1&#45
4 LPM Keep O2 sat 92&#45
95% ABG 4hr. later ,Initial setting FiO2 =0.4&#45
1.0 EPAP 4&#45
10 cmH2O Adjust Pressure target TV 6&#45
9 cc/kg Keep O2 sat 92&#45
95% follow up ABG 1 hr.and clinical then weaning setting decrease FiO2 0.2/hr. until Fio2 0.4 Keep O2 sat 92&#45
95% ABG 2 hr. later decrease IPAP 2 cmH2O/hr. until 8 decrease EPAP 2 cmH2O/hr. until 4 Keep O2 sat 92&#45
95%&#44
ABG 4 hr. later Oxygen cannula 1&#45
95% ABG 4hr. later
Experimental Device,Experimental Device
High flow nasal cannula ,Non &#45
invasive positive pressure ventilation

Sponsors

Ramathibodi hospital Mahidol university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 110 Years

Inclusion criteria

Inclusion criteria: Age more than 18 year and Define to Immunocompromised patient at least one; Hematologic malignancy&#44; Solid tumor&#44; HIV&#44; Steroid used (>0.3mg/kg/day > 1month)&#44; chemotherapy&#44; Immunosuppressive and Define to hypoxic respiratory failure; respiratory rate > 24 /min and pulse oximetry< 92% during oxygen cannula 4 LPM or Po2/Fio2< 300 or SatO2/Fio2<255

Exclusion criteria

Exclusion criteria: 1) COPD 2) Asthma 3) Congestive Heart Failure 4) PaCO2 >45 mmHg 5) Systolic Blood Pressure <90 mm Hg or Mean Arterial Blood pressure <65 mmHg 6) Glasgow coma scale <12 7) Circulatory shock or Receiving vasopressor 8) Met indication for Emergency intubation 9) Do not resuscitation Assign before

Design outcomes

Primary

MeasureTime frame
Intubation rate at Day 28 at Day 28 prospective recording data = n (%)—

Secondary

MeasureTime frame
28 day ventilator free day &#44; &#44; at Day 28 prospective recording data (day alive without ventilator support = day),28 day hospital free day at Day 28 prospective recording data (day alive without hospitalization = day),28 day mortality at Day 28 prospective recording data (mortality at Day 28 = N (%)—

Countries

Thailand

Contacts

Public Contactpitsucha sanguanwit

Ramathibodi hospital Mahidol university

pitsucha.san@mahidol.edu0841300301

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026