Comparing multimodality-guided transbronchial lung biopsy in small peripheral pulmonary nodules by thin bronchoscopy and electromagnetic navigation bronchoscopy, a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20200224003

Enrollment

Registered

2020-02-24

Start date

2016-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral pulmonary nodule lung nodule peripheral lung nodule peripheral pulmonary nodule electromagnetic navigation bronchoscopy thin bronchoscopy

Interventions

Bronchoscopic procedures were performed using local anesthesia with lidocaine and moderate conscious sedation with intravenous midazolam and fentanyl. When the target bronchus was located&#44

the R&#45

EBUS probe was inserted through the bronchoscopic working channel. When the EBUS image was obtained&#44

TBLB were performed under fluoroscopic guidance followed by bronchoalveolar lavage. The bronchus level reached with the bronchoscope&#44

the location of the EBUS probe related to the lesion on an EBUS image&#44

and procedure&#45

related complications were recorded. The biopsy specimens were immersed in 10% formalin and analyzed by pulmonary pathologists. Pneumothorax were screened using fluoroscopy in all patients immediately

histopathology and microbiology. Benign diseases were diagnosed if there was stability or improvement of the lesion on imaging for a minimum period of 24 months.,Pre&#45

procedural planning for identification of the target lesion&#44

airway path and registration points was performed after importing the CT data into the superDimension(TM) software. Bronchoscopic techniques were similar to the TB group except in performing under rea

time navigation. When the bronchoscope was located in the bronchus of interest&#44

the locatable guide was withdrawn and the R&#45

EBUS probe was inserted through the extended working channel (EWC). When the EBUS image was obtained&#44

TBLB was performed under fluoroscopic guidance followed by bronchoalveolar lavage.

Experimental Procedure/Surgery,Experimental Procedure/Surgery

Thin bronchoscopy,Electromagnetic navigation bronchoscopy

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age more than or equal to 18 2. Patients with peripheral pulmonary nodule less than or equal to 3 centimetres 3. No contraindication for bronchoscopy and transbronchial lung biopsy

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Presence of contraindication for bronchoscopy and transbronchial lung biopsy 3. No informed consent

Design outcomes

Primary

Measure	Time frame
Diagnostic yield of thin bronchoscopy and electromagnetic navigation bronchoscopy 24 months Percent	—

Secondary

Measure	Time frame
Factors affected the diagnostic yield 24 months Percent,Complications of thin bronchoscopy and electromagnetic navigation bronchoscopy At the end of procedure Percent	—

Countries

Thailand

Contacts

Public ContactSupparerk Disayabutr

Siriraj Hospital, Mahidol University

supparearg@gmail.com+66851595929

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Comparing multimodality&#45;guided transbronchial lung biopsy in small peripheral pulmonary nodules by thin bronchoscopy and electromagnetic navigation bronchoscopy&#44; a randomized controlled trial