COPD patients with exercise induced desaturation COPD exercise induced desaturation High flow nasal cannula
Conditions
Interventions
High flow nasal cannula(HFNC) Temperature 37 Flow 60 LPM Fractional of oxygen(FiO2) 0.4,Oxygen cannula 5 litre per minute(LPM),No oxygen supplement
Active Comparator Device,Active Comparator Device,Placebo Comparator No treatment
High flow nasal cannula,Oxygen cannula,No oxygen supplement
Sponsors
Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University Grant number RA62/129
None,None
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: Confirmed COPD diagnosis by spirometry. No exacerbation for 4 weeks before inclusion. Oxygen saturation at room air was at least 90%. During 6 minutes walk test, oxygen saturation was less than 90% or drop at least 4% from baseline. Can do cycle ergometry CPET
Exclusion criteria
Exclusion criteria: Contraindications for spirometry and CPET. Can't do complete pulmonary function tests(lung volume, DLCO) Underlying diseases eg. asthma, pulmonary hypertension, pulmonary fibrosis, pulmonary embolism, bronchiectasis, lung cancer, cardiac arrhythmia, anemia, severe allergic rhinitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endurance time Time that can do exercise at 70% constant work rate CPET Seconds/devided in 3 group: no oxygen, HFNC, oxygen cannula | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to desaturation Time that oxygen saturation drop 4% from baseline or < 90% Seconds/devided in 3 group: no oxygen, HFNC, oxygen cannula,Modified Borg scale Dyspnea score 0-10 0-10,Rated perceived exertion Rated perceived exertion 6-20 6-20 | — |
Contacts
Public ContactNatthawan Sanguanwong
King Chulalongkorn Memorial Hospital
Outcome results
None listed