allergic rhinitis allergic rhinitis herbal medicine
Conditions
Interventions
ACF78 is composed of 21 herbs
root of Ligusticum sinense Oliv. cv. Chuanxiong,
root of Premna herbacea Roxb,
root of Smilax corbularia Kunth,
root of Harrisonia perforate (Blanco) Merr,
heartwood of Santalum album L.,
heartwood of Dracaena cochinchinensis (Lour.) S.C. Chen,
root of Capparis micracantha DC.,
leave of Rhinacanthus nasutus (L.) Kurz,
root of Clerodendrum petasites (Lour.) S.Moore,
stamen of Nelumbo nucifera Gaertn,
seed of Coriandrum sativum L.,
heartwood of Caesalpinia sappan L.,
root of Zingiber montanum (J.KÖnig) Link ex A. Dietr,
root of Citrus hystrix DC.,
root of Citrus aurantiifolia (Christm.&Panz.) Swingle,
root of Bouea macrophylla Griff.,
root of Ficus racemosa L.,
leave of Clinacanthus nutans (Burm.f.) Lindau,
root of Imperata cylindrical (L.),
Sponsors
Routine to researh unit,Faculty of Medicine Siriraj Hospital Mahidol University
Routine to researh unit,
Faculty of Medicine Siriraj Hospital Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years who has been diagnosed with allergic rhinitis by a specialized medicine. 2. Positive reaction to one or more main allergens as evaluated in skin prick test or history within 1 year. 3. Inform consent was obtained before initiation.
Exclusion criteria
Exclusion criteria: 1. Presence of severe pathology within the nasal cavity for example chronic sinusitis, neoplasm, nasal polyp, deviated nasal septum. 2. Presence of abnormal liver function (AST or ALT ≥100 IU/L) or abnormal renal function (BUN ≥30 mg/dL or creatinine ≥1.8 mg/dL (male), 1.5 mg/dL (female)). 3. Active medical disorders such as cancer, infection, hematologic, renal, hepatic or cardiovascular. 4. History of allergic reactions from herbs, herbal medicines or pollen. 5. History of anaphylaxis. 6. Women who are pregnancy, lactation or plan to pregnancy. 7. History have been vaccinated by allergen immunotherapy within 2 years or have been taken antihistamine within 7 days 8. Use systematic corticosteroid within the last 3 months or nasal corticosteroid within the last 15 days. 9. Patients who were using any traditional Thai or Chinese therapy for 1 month before entering the study. 10. Chronic use of parallel medications (e.g., tricyclic antidepressants). 11. Presence of body temperature more than 37.5 degrees.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical evaluation 2 weeks Total symptom score,Quality of life questionnaire 2 weeks Rcq-36 ,Total nasal resistance 2 weeks active anterior rhinomanometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Lab evaluation 2 weeks blood analysis,Side effect record 2 weeks Naranjo’s algorithm,diary | — |
Contacts
Public ContactPravit Akarasereenont
Siriraj Applied Thai Traditional Medicine,Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed