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Association between Organic cation transporter 1 (OCT1) gene polymorphisms and gastrointestinal intolerance to metformin among Thai diabetic patients

Association between Organic cation transporter 1 (OCT1) gene polymorphisms and gastrointestinal intolerance to metformin among Thai diabetic patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20200218001
Enrollment
Unknown
Registered
2020-02-18
Start date
2018-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metformin is widely used oral hypoglycemic drug

Interventions

metformin tolerance,metformin intolerance
the patients who can use metformin dosage more than 2&#44
000 mg/day without GI side effects,the patients who can tolerate for using metformin dosage more than 2&#44
000 mg/day due to GI side effects
Health Services Research,Health Services Research

Sponsors

Ratchadapiseksompotch Fund, Faculty of Medicine. Chulalongkorn university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 100 Years

Inclusion criteria

Inclusion criteria: -age more than 20 years old -history of prescribed for metformin any dosage

Exclusion criteria

Exclusion criteria: -prgnancy -IBS -advanced cancer -patients who had contraindication for metformin use -cirrhosis CTP B,C

Design outcomes

Primary

MeasureTime frame
OCT1 polymorphism, rs628031 from August 2018 to February 2020 Direct DNA sequencing (Sanger sequencing)—

Secondary

MeasureTime frame
OCT1 polymorphism ; rs12208357, rs72552763 and rs1867 from August 2018 to February 2020 Direct DNA sequencing (Sanger sequencing)—

Countries

Thailand

Contacts

Public ContactPiyanuch Piyasatit

Faculty of Medicine, Chulalongkorn University

jajapiyapiya@gmail.com0818688361

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026