constipation constipation defecation yoghurt starter culture women
Conditions
Interventions
110 g of commercially available Bulgarian yoghurt (natural flavor) The yoghurt was made from LB 81 (Lactobacillus bulgaricus) and Streptococcus thermophilus,110 g of acidified milk curd made by adding
Active Comparator Dietary Supplement,Placebo Comparator Dietary Supplement
Bulgarian yoghurt,Placebo
Sponsors
CP-Meji Co, Ltd.
Mahidol University,Mahidol University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Female Age 18-50 years old Having at least 2 following symptoms - defecation < 3 times per week - straining - lumpy or hard stool - sense of anorectal obstruction - sense of incomplete evacuation Able to continuously consume yoghurt for three weeks
Exclusion criteria
Exclusion criteria: Pregnancy or plan for pregnancy Lactose intolerance Binge drinking or chronic alcoholism Undergo GI surgery including bariatric surgery During chemotherapy or opioid treatment History of chronic psychotic disorders Having irritable bowel syndrome (IBS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in defecation frequency Self report daily throught 12 weeks and follow-up 0, 3, 6, 9, 12 weeks Subject diaries and frequency questionaire,Changes in defecation symptoms Follow-up 0, 3, 6, 9, 12 weeks Interview and questionaire using ROME IV criteria, Constipation Assessment Scale (CAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in mood status Self report daily throught 12 weeks and follow-up 0, 3, 6, 9, 12 weeks Subject diaries recording Mood score using mood thermometer ,Changes in fecal bacteria varieties Follow-up 0, 3, 6, 9, 12 weeks Microbiome analysis of feces sample using 16s DNA sequencing and bioinformatics ,Changes in short-chain fatty acids and volatile acids Follow-up 0, 3, 6, 9, 12 weeks GC-MS and HPLC analysis of feces sample,Changes in body weight, body composition and waist circumference Follow-up 0, 3, 6, 9, 12 weeks Bioelectrical impedance analysis (BIA) and measuring tape,Changes in constipation related quality of life Follow-up 0, 3, 6, 9, 12 weeks Questionaire | — |
Contacts
Public ContactDunyaporn Trachootham
Institute of Nutrition, Mahidol University
Outcome results
None listed