Patients who were diagnosed as Parkinson'
Conditions
Interventions
Prucalopride 2 mg/day,A placebo pill in an identicle fashion
Experimental Drug,Placebo Comparator No treatment
Sponsors
Faculty of Medicine, Siriraj Hospital
Faculty of Medicine,
Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria - patients who age of >/=18 years old - Has been diagnosed as Parkinson disease according to UKPDS Brain bank criteria who are in stable disease (no need for medication adjustment at least 4 weeks before enrollment. - Met criteria of chronic constipation according to ROME IV criteria (ROME IV diagnosis criteria for constipation)
Exclusion criteria
Exclusion criteria: Exclusion Criteria - Had alternative cause of chronic constipation eg. o History of abdominal surgery except anorectal surgery, appendectomy and cholecystectomy. o Recieve drugs which effect GI motility eg. opioids, anticholinergic agents o Have endrocrinologic disease or metabolic derangement which caused constipation eg.hypothyroidism, hypercalcemia o megacolon/megarectum, pseudo-colonic obstruction - Has been diagnosed as colonic cancer before the enrolment all participants with age 50 year should be underwent colonic cancer screening - Allergic to prucalopride or medication component. - Currently treated with prucalopride before the enrollment. - Severe dementia or unable to fill the questionnaires. - Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy of medication week 2, 4 and 8 frequency of bowel movement | — |
Secondary
| Measure | Time frame |
|---|---|
| constipation related quality of life week 2, 4 and 8 questionnaire | — |
Countries
Thailand
Contacts
Public ContactMonthira Maneerattanaporn
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed