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Protocol of PEEP Decrement Guided by Lung Volume Changes Shortens Time to Spontaneous Breathing Trial in Recovering ARDS Patients: A Randomized Controlled Trial

Protocol of PEEP Decrement Guided by Lung Volume Changes Shortens Time to Spontaneous Breathing Trial in Recovering ARDS Patients: A Randomized Controlled Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20200206001
Enrollment
68
Registered
2020-02-06
Start date
2019-01-15
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with recovering ARDS who are assisted with mechanical ventilation Protocol Lung volume change PEEP Decrement Time to Spontaneous Breathing Trial Recovering ARDS

Interventions

If end expiratory lung volume decreases more than 10%&#44
stop PEEP decrement In contrast&#44
if end expiratory lung volume decrease equal or less than 10%&#44
continue PEEP decrement ,PEEP decrement regardless of end expiratory lung volume changes
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
PEEP Decremental Protocol Guided by Lung volume changes,Usual Care

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients with recovering ARDS who are assisted with mechanical ventilation patients with PF ratio > 150 patients assisted with PEEP at least 8 cmH2O patients assisted with FiO2 equal or less than 60% to keep SpO2 >90% patients with stable condition and stable FiO2 > 24 hours

Exclusion criteria

Exclusion criteria: Age < 18 years old Pneumothorax&#44; Hemothorax&#44; recent thoracic surgery Active heart disease COPD or lung bleb pregnancy

Design outcomes

Primary

MeasureTime frame
time to SBT during study period number

Secondary

MeasureTime frame
Lung Collapse events during study period number,Lung collapse predictors during study period number

Countries

Thailand

Contacts

Public Contactnapplika kongpolprom

Thai Red Cross Society

napplika@yahoo.com0909617486

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026