Intestinal permeability Gastrointestinal symptoms Intestinal permeability Urine Lactulose and Mannitol ratio Bloating Crohn’s disease
Conditions
Interventions
All participants were overnight fasted and morning urine samples were collected as baseline. After ingestion of 100 ml solution of 5 g lactulose and 2 g mannitol in water,
urine samples were serially collected at 2,
4 and 6 hour. ,All participants were overnight fasted and morning urine samples were collected as baseline. After ingestion of 100 ml solution of 5 g lactulose and 2 g mannitol in water,
4 and 6 hour.
Measurement of percentage excretion of urine lactulose and mannitol in healthy volunteer,Measurement of percentage excretion of urine lactulose and mannitol in functional bloating,Measurement of perce
Sponsors
Siriraj Medical Research Ceter (SiMR)
Division of Gastroenterology,
Department of Medicine,
Siriraj hospital,
Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1 Age 18-65 year 2 Population group 2.1 Healthy Or 2.2 Patient with Functional bloating or Functional gastro-intestinal disorder From Rome IV criteria Or 2.3 Patient with small bowel Crohn’s disease with disease activity from CDAI >= 220
Exclusion criteria
Exclusion criteria: 1 Previous bowel resection 2 Uncontrolled underlying diseases 3 Active smoking or drinking 4 Using medications included NSIADs, antispasmodic and prokinetics agents within 2 weeks prior to study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal permeability 2, 4 and 6 hours after ingestion ratio of percentage excretion of lactulose and mannitol in urine (uLMR) | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms and Quality of life Before and after Modified GIS rating scale and GIQoL ,Safety and tolerability After Symptoms | — |
Contacts
Public ContactMonthira Maneerattanaporn
Division of Gastroenterology, Department of Medicine, Siriraj hospital, Mahidol University
Outcome results
None listed