Intradialytic hypotension Intradialytic hypotension Mineralocorticoid receptor agonist
Conditions
Interventions
Patients in intervention arm will be prescribed 2 tablets (0.2 mg) of fludocortisone 30 minutes prior to undergo hemodialysis in every sessions during study period.,Patients in controlled arm will und
Experimental Drug,No Intervention No treatment
Fludocortisone,No intervention
Sponsors
Lampang hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: - ESRD patients (defined by Kidney Disease Initiative Global Outcome (KDIGO) Guideline 2012) requiring chronic hemodialysis - Hemodialysis vintage more than 3 months - Hemodialysis with 2 sessions per week - History of intradialytic hypotension at least 30% of their dialysis sessions during the past 3 months
Exclusion criteria
Exclusion criteria: - Active cardiac, pulmonary or hepatobiliary tract disease - Active infection or sepsis - Systemic fungal infection - Require ultrafiltration more than 4L per session - Active malignancy - Prior treatment with fludocortisone in past 4 weeks - Contraindication to fludocortisone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of events of intradilytic hypotension by KDOQI 2002 criteria During hemodialysis Number of events (%) ,Change of Intradialytic blood pressure During hemodialysis mmHg | — |
Secondary
| Measure | Time frame |
|---|---|
| Intradialytic hemodynamic parameters During hemodialysis Blood pressure (mmHg), heart rate (bpm),Number of events of intradilytic hypotension by KDOQI 2002 criteria During hemodialysis Number of events (%) | — |
Countries
Thailand
Contacts
Public ContactThanawat Vongchaiudomchoke
Department of internal medicine, Lampang hospital
Outcome results
None listed