Aneurysmal subarachnoid hemorrhage Cerebral Vasospasm aneurysm vasospasm intra-
Conditions
Interventions
The intervention group received intra-
arterial Nimodipine infusion in a dosage range of 1-
5 mg in each vessel,
at the rate of 1 mg per 5 minutes (maximum dosage must not exceed 10 mg) directly into the artery in which a 5-
French vertebral catheter was placed in the cervical region. The total dosage of Nimodipine infusion depended on significant angiographic improvement and was observed for any complications,
such as hypotension and bradycardia,No intra-
arterial nimodipine infusion
Experimental Drug,No Intervention No treatment
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ASAH patients, ranging in age 18 - 80 years, on whom aneurysm obliteration was performed, either by surgical clipping or endovascular therapy After aneurysm obliteration, digital subtraction diagnostic angiography was performed on all patients. If angiographic vasospasm was demonstrated, we enrolled the patients, whether or not they suffered any clinical vasospasm, such as alteration of consciousness, new motor deficits, or unexplained fever. Consent was informed and obtained from the patients or their relatives, as appropriate Every angiography was done within 14 days, according to the date of rupture, otherwise the case was excluded. After we found any angiographic vasospasm (defined as any acute tapering or focal vasoconstriction of any vessels compared to prior diagnostic imaging), we categorized patients into good neurological baseline group, defined as World Federation of Neurological Surgeons’ score (WFNS) grade I-III, and poor neurological baseline group defined as WFNS grade IV-V first, and then performing block randomization into 1:1 of the intervention and control groups
Exclusion criteria
Exclusion criteria: No angiographic vasospasm Angiography done after 14 days Denied consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological Outcome 6 months after intervention WFNS, Glasgow Coma Scale (GCS), and motor power, Glasgow Outcome Scale (GOS), modified Rankin Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Angiographic outcome After intervention caliber of vessels suspected of vasospasm | — |
Countries
Thailand
Contacts
Public ContactVich Yindeedej
Thammasat University Hospital
Outcome results
None listed