Critically-
Conditions
Interventions
Accusol-
35 will be used as a replacement fluid. The component of this fluid include [Na+] 140 mmol/L,
[K+] 0 mmol/L,
[Cl-
] 109.5 mmol/L,
[HCO3-
] 35 mmol/L,
[Mg2+] 0.5 mmol/L,
and [Ca2+] 1.75 mmol/L. ,High-
sodium replacement fluid will be generated by a mix of Accusol-
35 5,
000 ml and 3% NaCl 100 ml. The component of this mixing fluid will include [Na+] 147.3 mmol/L,
] 117.4 mmol/L,
] 34.3 mmol/L,
[Mg2+] 0.49 mmol/L,
and [Ca2+] 1.72 mmol/L.
Active Comparator Other,Experimental Other
Sponsors
Division of Nephrology, Department of Internal Medicine, Faculty of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age of 18 years or more 2. ICU patients requiring continuous renal replacement therapy 3. Patients with adequate volume status assessed by inferior vena cava distensibility index <18 % or pulse pressure variation < 13 % 4. Patients who are being on inotropic agents 5. Patients or family members can provide consent
Exclusion criteria
Exclusion criteria: 1. Patients with serum sodium levels <125 mmol/L 2. Patients with mean arterial pressure <65 mmHg with adequate dose of inotropic agents 3. Patients with severe acidosis (defined by blood pH <7.15) 4. Pregnancy 5. Uncontrolled bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients who have vasopressor dependency index change of ≥0.05 4 hours after randomization Vasopressor dependency index is calculated from inotropic score divided by mean arterial pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of patients who have vasopressor dependency index change of ≥0.05 8, 16, and 24 hours after randomization Vasopressor dependency index is calculated from inotropic score divided by mean arterial pressure,Changes of mean arterial blood pressure from baseline 4, 8, 16, and 24 hours after randomization Blood pressure is measured by standard methods with automatic machine,Changs of blood lactate from baseline 8 hours after randomization Blood lactate is measured by hospital central laboratory unit using standard technique,์Number of days using inotropic agents From randomization until reach endpoint of interest or patient death Number of days counting from randomization to the last day using inotropic agents,์Number of days requiring continuous dialysis therapy From randomization until reach endpoint of interest or patient death Number of days counting from randomization to the last day requiring continuous dialysis therapy,Mortality rate at day 7 and day 28 after randomization and in-hospital Declaration of in-hospital death by attending physicians | — |
Countries
Thailand
Contacts
Public ContactKajohnsak Noppakun
Chiang Mai University
Outcome results
None listed