Irritable bowel syndrome characterized by chronically recurring abdominal pain or discomfort and altered bowel habits,
Conditions
Interventions
Thatbunjob consists of 22 plants. One capsule of Thatbunjob contains 500 mg of herbal powder drug.,Corn starch has no side effect on IBS patients. It is used as placebo in this project. One capsule of
Experimental Drug,Placebo Comparator Drug
Thatbunob capsule,Corn starch
Sponsors
Faculty of medicine, Thammasat University
Faculty of Medicine,
Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Abdominal pain at least 1 day per week for the past 3 months associated with two or more of the following: -Improvement with defecation -Onset associated with a change in frequency of stool
Exclusion criteria
Exclusion criteria: 1.Indication or contraindication to antiplatelet or anticoagulant therapy. 2.A clinically significant bleeding diathesis. 3. Positive pregnancy test, breast feeding 4. Risk of colon cancer include - Weight loss > 10% in the previous 3 months. - Positive of stool occult blood - Anemia -Hepatomegaly, gastric tumor, Lymphadenopathy, jaundice - Family history of colon cancer 5) Inconvenience to go to Thammasat hospital 6) ALT is higher than 3 times of upper limit of normal 7) eGFR is lower than 60 mL/min 8) Allergic to herbal drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain, Bloating and stool frequency of IBS IBS symtom will be recorded by the participant daily until Day 1 to Day 21 Pain score, Bloating score and stool frequency score | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life The begining of the study and Day 21 EQ5D5L of EuroQol Research Foundation ,Side effect of Thatbunjob 1 day and 7 days after stopping drug study Blood test for AST, ALT, creatinine, eGFR, CBC | — |
Countries
Thailand
Contacts
Public ContactPatommatat Bhanthumkomol
Faculty of Medicine, Thammasat university
Outcome results
None listed