Patients with vascular pythiosis pythiosis P.insidiosum azithromycin itraconazole doxycycline
Conditions
Interventions
All patients need radical surgery to remove all infected tissues if feasible in conjunction with itraconazole 200 mg q 8 h,
azithromycin 500 mg daily and doxycycline 100 mg q 12 h
Experimental Drug
Surgery with antimicrobial agents
Sponsors
Health Systems Research Institute
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patient age of 18 years or above 2. Patient is diagnosed with human pythiosis based on clinical presentation and additional 2 out of 4 criteria below; - Patient has positive serum P. insidiosum antibody based on in-house enzyme-linked immunosorbent assay (ELISA) - Positive cultures for P. insidiosum, confirmed by zoospore induction and nucleic acid sequencing, from tissue samples - Consistent pathological finding with broad-sized hyaline septate hyphae in tissues - Detection P. insidiosum DNA by polymerase chain reaction (PCR) in tissue samples
Exclusion criteria
Exclusion criteria: 1. Patient has other concurrent fungal infection 2. Patient is not willing to follow up according to the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study mortality in vascular pythiosis after using antibacterial agents as a part of treatment reg 6 months and 1 year after diagnosis Descriptive statistics | — |
Secondary
| Measure | Time frame |
|---|---|
| To study in vitro susceptibility of antibacterial and antifungal agents against P.insidiosum isolate N/A N/A,To study correlation between ESR, CRP and serum (1,3) beta-d-glucan and P.insidiosum antibody N/A Spearman's correlation coefficient and longitudinal regression,To study itraconazole level in correlation with itraconazole MIC and clinical outcomes N/A Descriptive statistics | — |
Countries
Thailand
Contacts
Public ContactNitipong Permpalung
Faculty of Medicine, Chulalongkorn University; Johns Hopkins University School of Medicine
Outcome results
None listed