levothyroxine absortption levothyroxine absorption soy milk
Conditions
Interventions
Levothyroxine absorption test while consumed Levothyroxine with water,Levothyroxine absorption test while consumed Levothyroxine with soy milk
Placebo Comparator Drug,Active Comparator Drug
Levothyroxine absorption with water,Levothyroxine absorption with soy milk
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers 2. Aged 18-45 years 3. Written informed consent by volunteer
Exclusion criteria
Exclusion criteria: 1. Adults with recent acute illness, cardiovascular disease/abnormal electrocardiogram, renal insufficiency (serum creatinine >1.5 mg/dL), abnormal liver function (AST and/or ALT > 3 times of upper normal limit) 2. Use of certain medications that interfere with levothyroxine absorption such as iron, calcium, proton pump inhibitor, sucralfate, aluminium hydroxide, cholestyramine; affect with levothyroxine metabolism such as phenytoin, carbamazepine, phenobarbital, rifampicin, tyrosine kinase inhibitor 3. Use of certain medications that alter thyroid hormone levels such as amiodaraone, lithium, interfereon-alpha, alemtuzumab, glucocorticoid, somatostatin 4. Use of certain medications that affect with thyroxine-binding globulin such as estrogen, raloxifene, tamoxifen, mitotane, fluorouracil, methadone, heroin, androgen, nicotinic acid 5. Adults who had intestinal absorption problem or history of gastric/intestinal surgery 6. Adults with allergy to soy and/or levothyroxine 7. Pregnant women/lactating women 8. Adults who has abnormal TSH concentrations 9. Denied to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levothyroxine absorption test October 2019-September 2020 Area under the curve (AUC) of serum total T4 concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| analgesic usage until patient get operative fixation morphine dose requirement,complication until patient get operative fixation observe ex pressure sore peroneal nerve palsy | — |
Countries
Thailand
Contacts
Public ContactChutintorn Sriphrapradang
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Ho
Outcome results
None listed