Fentanyl-induced cough is commonly occurred, especially in pre anesthetic induction between 18% and 65% and lidocaine can alleviate the incidence and severity of cough. Therefore, the objective of the present study was to demonstrate efficacy of low dosage of lidocaine attenuate FIC Cough, Fenanyl, Lidocaine, low dose
Conditions
Interventions
Normal saline were injected within 3-4 seconds before two minute of 3 microgram/kg intravenous fentanyl between 3-4 seconds. A stopwatch was monitored during the injection periods. Subsequently, anaes
placebo,lidocaine 0.25mg/kg,lidocaine 0.5mg/kg,lidocaine 1mg/kg
Sponsors
Phramongkutklao Hospital and Collage of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ASA class 1-2
Exclusion criteria
Exclusion criteria: Patients were unwilling to participate, had a history of allergy to lidocaine or fentanyl, history of chronic obstructive pulmonary disease, bronchial asthma, recent respiratory tract infection less than 2 weeks, impaired kidney or liver function, or had been treated with angiotensin converting enzyme inhibitors or beta blocker, symptomatic bradycardia, tachyarrhythmia, left bundle branch block and second or third-degree atrioventricular block, pregnancy and language barrier.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cough 3 minutes after fentanyl injection Incidence of cough | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of cough 3 minutes after fentanyl injection The number of episodes of cough (mild,moderate,severe),Risk factor of cough 3 minutes after fentanyl injection Identified risk from all data variables,Hemodynamic response 3 minutes before fentanyl injection (baseline) and at 3 minutes after starting fentanyl injections NIBP,EKG,SpO2 was measured | — |
Countries
Thailand
Contacts
Public ContactSithapan Munjupong
Phramongkutklao Hospital
Outcome results
None listed