spontaneous intraventricular hemorrhage secondary intraventricular hemorrhage from spontaneous intracerebral hemorhage obstructive hydrocephalus intraventricular hemorrhage hydrocephalus fibrinolytic agent endoscopic removal
Conditions
Interventions
external ventricular drainage plus fibrinolytic agents and/or endoscopic intraventricular clot removal,external ventricular drainage alone
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. age 18-80 years 2. onset less than 24 hours prior to CT brain 3. primary intraventricular hemorrhage or secondary from spontaneous intracerebral hemorrhage less than 20 ml 4. obstructive hydrocephalus from blood clot in 3rd or 4th ventricles 5. SBP < 200 mmHg or MAP <130 mmHg prior to treatment 6. Modified Rankin Scale 0 or 1 before onset
Exclusion criteria
Exclusion criteria: 1. Ruptured aneurysm, arteriovenous malformation (AVM), vascular anomaly, Moya-moya disease disease or tumor 2. previous brain surgery less than 3 months 3. uncorrectable bleeding disorders, platelet count less than 100,000, or INR more than 1.3 4. pregnancy 5. infratentorium hemorrhage 6. severe unstable medical conditions such as uncontrolled cardiac disease 7. subjects refuse to participate, unidentifiable subject, or unable to find consent for subject
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale (mRS) Posttreatment 6 month mRS 0-3 vs 0-6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale (mRS) Posttreatment 3 month mRS 0-3 vs 0-6,Mortality rate entire study mortality event,Quality of life Posttreatment 1, 3 and 6month EQ 5D 5L,Rate of shunt surgery entire study event of shunt surgery,Complications entire study complication event rate | — |
Countries
Thailand
Contacts
Public ContactRaywat Noiphithak
Thammasat University Hospital
Outcome results
None listed